See Provider section below See Pharmacist and Nurse section below Spironolactone, One of the More Versatile Drugs Spironolactone is a prescription medication used to treat several different health conditions, making it one of the more versatile drugs in everyday medical practice. It is classified as a potassium-sparing diuretic , sometimes called a “water pill,” but its effects go beyond simply helping the body get rid of extra fluid. Spironolactone works by blocking the acti